← brief for 2026-09-04 · Slowing decline

The Cardio-Renal-Hepatic Axis in MASLD. Role of BDNF, NGF, and Metabolic Cross-Talk.

Key takeaways

This review looks at how fatty liver disease harms the heart and kidneys together. Fat building up in the liver appears to trigger heart damage and kidney damage through shared chemical signals, including two nerve growth proteins called BDNF and NGF. The authors argue these shared signals could become drug targets for all three organs at once. It is a summary of existing research, so there are no new results.

Who did this work

Taylor LC · Adenawoola MI · Wingfield CB · Nadolski MK · Stec DE

Source

Article · PubMed, the drug frontier · 2026 Sep 4
https://pubmed.ncbi.nlm.nih.gov/42693357/