← brief for 2026-09-04 · Slowing decline

Role of mitochondria-associated ER membranes in lipid metabolism: implications for renal lipotoxicity.

Key takeaways

This review explains how fat handling goes wrong inside kidney cells and may drive damage in diabetic kidney disease, sudden kidney injury and chronic kidney disease. It focuses on contact points where two parts of the cell, the mitochondria and the endoplasmic reticulum, meet and trade fats and calcium. The authors say it is still unclear whether this causes kidney damage or just goes along with it. This is a summary of other people's work, so there are no new results.

Who did this work

Gao Y · Shao M · Fang Y · Zeng J · Sun H

Source

Article · PubMed, the drug frontier · 2026 Sep 16
https://pubmed.ncbi.nlm.nih.gov/42693812/