← brief for 2026-09-04 · Slowing decline

Rituximab therapy achieves comparable remission to cyclophosphamide in ANCA-associated vasculitis with severe KIDNEY involvement

Key takeaways

ANCA-associated vasculitis is an immune disease that attacks small blood vessels, including those in the kidneys. This study compared two drugs used to calm it down: rituximab and cyclophosphamide, an older chemotherapy drug. In people with severe kidney involvement, rituximab put about the same share of patients into remission. This compared groups of patients who were already treated, so it shows the two look similar, not that one causes a better outcome.

Who did this work

Nishant Chaudhari (University Hospitals Birmingham NHS Foundation Trust) · Azm Ul Hussain (University Hospitals Birmingham NHS Foundation Trust) · Lee Quill (University Hospitals Birmingham NHS Foundation Trust) · Joshua Harridine (University Hospitals Birmingham NHS Foundation Trust) · Kashif Eqbal (University Hospitals Birmingham NHS Foundation Trust) · Lorraine Harper (Birmingham City University) · Dimitrios Chanouzas (University Hospitals Birmingham NHS Foundation Trust)

Source

Paper · OpenAlex, Kidney disease concept sweep (verified C2778653478) · 2026-09-03
https://doi.org/10.1093/ckj/sfag290