← brief for 2026-09-04 · Slowing decline

Necroptosis–senescence crosstalk in tubulointerstitial fibrosis: the mtDNA–cGAS–STING–PFKFB3 axis as a metabolic bridge

Key takeaways

This is a review paper about how kidney cells die and age, and how that leads to scarring in the kidney filter tubes. It walks through a chain of molecules that starts when damaged cell power plants leak their DNA and sets off an alarm system inside the cell. The work behind it comes from cells and animals, not people, and this paper reports no new results of its own. Nothing here is a treatment anyone can use yet.

Who did this work

王东晖 (Nanjing University of Chinese Medicine) · Hongxiang Zheng (Nanjing University of Chinese Medicine) · Xinyue Zhang (Nanjing University of Chinese Medicine) · Chenghua Zhang (Nanjing University of Chinese Medicine) · Dandan Zhao (Nanjing University of Chinese Medicine) · Shuqi Min (Nanjing University of Chinese Medicine) · Shenju Wang (Nanjing University of Chinese Medicine)

Source

Paper · OpenAlex, CKD works · 2026-09-03
https://doi.org/10.3389/fmed.2026.1882589