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Metformin-Associated Lactic Acidosis and Relative Euglycemic Ketoacidosis Precipitated by a Glucagon-Like Peptide-1 Receptor Agonist: A Case Report and Literature Review.

Key takeaways

A person taking metformin for diabetes became severely ill with acid buildup in the blood after starting a GLP-1 drug. This complication is rare, fewer than 10 cases per 100,000 patient-years, but 30 to 50 out of every 100 people who get it die. It usually starts when the kidneys suddenly stop working well, so metformin builds up in the body. This is one case plus a look back at past cases, so it shows a link worth watching, not proof of cause.

Who did this work

Adnani H · Ladiwala Z · Lee M · Patel A · King J · Weir MR

Source

Article · PubMed, the drug frontier · 2026 Sep 4
https://pubmed.ncbi.nlm.nih.gov/42696402/