← brief for 2026-09-04 · Slowing decline

Macrophage FOXO1 Inhibition Protects Against Hyperglycaemia‐Associated Kidney Injury

Paper D Peer reviewed Preclinical

Key takeaways

Blocking a protein called FOXO1 inside immune cells known as macrophages protected kidneys from damage caused by high blood sugar. This work was done in animals and cells, not in people yet. It suggests a possible future drug target for kidney disease in diabetes. Nothing here shows whether it would help a patient.

Who did this work

Hejie Zhu (Xinjiang Medical University) · Qian Liu (Peking University) · Lunqiang Yang (Xinjiang Medical University) · 张辰宇 (Peking University) · Ying Zhang (Peking University) · Ruiqi Zhao (Peking University) · Zhongyuan Zheng (Peking University) · Xi Wang (Peking University) · Linlin Li (Xinjiang Medical University) · Long Zhang (Peking University) · Lu Tie (Peking University)

Source

Paper · OpenAlex, Kidney disease concept sweep (verified C2778653478) · 2026-09-03
https://doi.org/10.1111/bcpt.70296