← brief for 2026-09-04 · Slowing decline

Indoxyl sulfate–associated vascular calcification is linked to mTORC1 and ER stress–integrated stress response signaling

Key takeaways

Indoxyl sulfate is a waste product that failing kidneys cannot clear well, and it builds up and hardens blood vessels. This lab work traced how it does that, pointing to two stress pathways inside blood vessel cells. Blocking those pathways reduced the hardening in the experiments. This was done in cells and animals, not in people, so no one should change treatment based on it.

Who did this work

Yan Zhang (Jewish General Hospital) · Dibyendu K. Panda (Jewish General Hospital) · Xiuying Bai (Jewish General Hospital) · Andrew C. Karaplis (Jewish General Hospital) · Mark L. Lipman (Jewish General Hospital)

Source

Paper · OpenAlex, CKD works · 2026-09-03
https://doi.org/10.1038/s41598-026-68457-y