← brief for 2026-09-04 · Regeneration & devices

Generation of the functionally enhanced proximal tubular cells from human iPSC-derived kidney organoids.

Article D Peer reviewed Preclinical

Key takeaways

Scientists turned human stem cells into small lab grown kidney tissue balls, then pulled out the filtering tube cells and made them work better. Two additions did the trick: a sugar based scaffold protein and a drug that blocks a scarring signal called TGF-beta. Better lab tubule cells would help researchers study kidney damage and test drugs. This was cells in a dish, not people yet.

Who did this work

Kim S · Nam SA · Kim JW · Yi J · Woo JJ · Lee M · Lee J · Kim TH · Kim H · Kim HW · Park J · Kim YK

Source

Article · PubMed, organoids & devices · 2026 Sep 3
https://pubmed.ncbi.nlm.nih.gov/42693236/