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Fibroblast Growth Factor 23 (FGF23): From Synthesis to Cleavage.

Key takeaways

FGF23 is a hormone made in bone that tells the kidneys to flush out extra phosphate, a mineral that comes from food. This review explains how the body builds FGF23, how the kidney recognizes it using a partner protein called Klotho, and how the hormone is later cut apart to shut it off. FGF23 in the blood rises early in kidney disease, often before other blood tests look abnormal, which is why it draws so much attention. It is a summary of laboratory work, not a new study, so there are no new results in people.

Who did this work

Yuan S · Wang Q · Meng C · Ji H · Li B

Source

Article · PubMed, Nutritional supplements and CKD · 2026 Sep 4
https://pubmed.ncbi.nlm.nih.gov/42697502/