← brief for 2026-09-04 · Slowing decline

Disproportionate reporting of euglycaemic and diabetic ketoacidosis with SGLT-2 inhibitors across expanding cardiorenal indications: a cross-database study of FAERS and JADER

Paper C Peer reviewed Observational

Key takeaways

Researchers searched two large drug side effect databases, one in the United States and one in Japan, and found ketoacidosis reported more often than expected with SGLT2 inhibitor pills. Ketoacidosis is a dangerous buildup of acid in the blood, and with these drugs it can happen even when blood sugar looks normal. These databases count reports, not patients, so this flags a safety signal to watch. It does not prove how often it happens or that the drug is the cause.

Who did this work

Jinqian Chen (Tianjin Infectious Diseases Hospital) · Deyin Wang (Tianjin Medical University) · Xiaochuan Duan (Tianjin Infectious Diseases Hospital) · Jianbo Wang (Tianjin Infectious Diseases Hospital) · Zhenyu Zhao (Tianjin Infectious Diseases Hospital) · Xiaolong Xing (Nankai University)

Source

Paper · OpenAlex, Kidney disease concept sweep (verified C2778653478) · 2026-09-03
https://doi.org/10.3389/fendo.2026.1957734