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Statins In Dialysis-Dependent End-Stage Renal Disease: Reconciling Discordant Evidence Through GRADE-Informed Appraisal and Evidence-to-Decision Framework.

Paper A Peer reviewed Meta-analysis or large trial

Key takeaways

This review examined why statins appear to help in observational studies but not in randomized trials for people on dialysis. It found the difference likely comes from how patients were selected — sicker people often don’t get statins, making the drug look less effective in trials. For people on dialysis, the review says statins probably do not lower heart risk enough to outweigh side effects like muscle pain.

Who did this work

Abdelnabi M (Department of Cardiovascular Medicine, Mayo Clinic, Phoenix, Arizona, USA.) · Ibrahim R · Elalfy A · Arsanjani R

Source

Paper · Europe PMC, CKD · 2026-08-28
https://doi.org/10.1097/fjc.0000000000001876