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Effect of In-Hospital Initiation of Dapagliflozin on Decongestion in Patients Hospitalized for Heart Failure: An Analysis of the DAPA ACT HF-TIMI 68 Trial.

Article A Peer reviewed Meta-analysis or large trial

Key takeaways

In 1,207 people hospitalized for heart failure, dapagliflozin helped remove extra fluid faster than placebo — 68% reached full decongestion by day 3, compared to 59% on placebo. This was a large, pre-planned analysis of a randomized trial, so the result is strong evidence that this drug helps protect kidneys during heart failure hospital stays.

Who did this work

Small AM · Patel SM · Thomas C · Palazzolo MG · Bělohlávek J · Desai AS · Drożdż J · Inzucchi SE · McMurray JJV · Merkely B · O'Meara E · Verma S

Source

Article · PubMed, the drug frontier · 2026 Aug 30
https://pubmed.ncbi.nlm.nih.gov/42669075/