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Clonal haematopoiesis and cardiovascular-kidney-metabolic syndrome: a cohort study.

Article C Peer reviewed Observational

Key takeaways

As people age, some of their blood-making stem cells pick up mutations. Doctors call this CHIP, and it has already been tied to heart disease and diabetes. This study used UK Biobank records to ask, for the first time, whether CHIP is also tied to the combined heart, kidney, and metabolic syndrome that groups those problems together. It is an observational cohort, so it can show a connection, not proof that these mutations cause kidney or heart damage.

Who did this work

Chang A · Li L · Ezzat D · Flynn S · De Moor N · Hemeryck J · Mohammadnia N · Schuermans A · Yu Z · Liu Y · Uddin MM · Natarajan P

Source

Article · PubMed, CKD progression and prevention · 2026 Aug 30
https://pubmed.ncbi.nlm.nih.gov/42668426/