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Hyperglycemia and alteration in sphingolipids are early mediators of diabetic kidney disease: role of elongase 1 (Elovl1)

Paper D Peer reviewed Preclinical

Key takeaways

Researchers found that high blood sugar changes certain fats called sphingolipids in the kidney, and that an enzyme named Elovl1 drives part of this. They point to it as one of the first steps in diabetes-related kidney damage. This was laboratory work in animals and cells, not people yet, so it suggests a target for future drugs rather than a treatment anyone can use.

Who did this work

Waleed O. Twal · Peggi M. Angel (2234191) · Kristi L. Helke · Alexander Awgulewitsch · Jason Pierce · Rebecca Gregory · Juan Torres · Yuan Shao · Carsten Krieg · Silvia Guglietta · Mrinmoyee Majumder · Nahla Hamouda

Source

Paper · OpenAlex, Kidney disease concept sweep (verified C2778653478) · 2026-08-28
https://doi.org/10.1159/000552867