← brief for 2026-08-28 · Regeneration & devices

Neutrophil gelatinase-associated lipocalin and kidney injury Molecule-1 as potential biomarkers of the transition from rhabdomyolysis-induced acute kidney injury to chronic kidney disease.

Article D Peer reviewed Preclinical

Key takeaways

Sudden kidney injury sometimes never fully heals and turns into long term kidney disease, and standard kidney tests are poor at spotting that turn. Researchers tested two proteins, NGAL and KIM-1, as early warning signs of bad healing after kidney injury caused by muscle breakdown, which floods the kidneys with a damaging protein. Both markers tracked the failed repair better than the usual function tests. This was done in animals, not people, so it is not a test a patient can ask for yet.

Who did this work

Esquivel Souza I · de Oliveira Torres B · da Silva Barbosa LD · Hora PS · Ferreira Silva V · de Oliveira Freitas W · Souza CS · de Araújo FA · de Jesus RLC · de Magalhães Gusmão ACM · Silva DF · Amaral LB

Source

Article · PubMed, CKD severity and reversal · 2026 Aug 25
https://pubmed.ncbi.nlm.nih.gov/42664824/