← brief for 2026-08-28 · Regeneration & devices

Myeloid myeloid PRDM16 restrains macrophage inflammatory remodeling and renal fibrosis in diabetic kidney disease by limiting PI3K/AKT activation.

Key takeaways

In mice and test-tube cells, a protein called PRDM16 in immune cells helped lower kidney scarring in diabetic disease by blocking one signaling pathway. This was not tested in people, so it is too early to say if this would help patients.

Who did this work

Wang S · Zhang T · He M

Source

Article · PubMed, fibrosis reversal · 2026 Aug 28
https://pubmed.ncbi.nlm.nih.gov/42663637/