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Forsythoside A Alleviates Hypertensive Nephropathy by Promoting Mitophagy and Inhibiting Ferroptosis via ASCL1-CCNB1/mTOR Pathway.

Key takeaways

Forsythoside A is the main active compound in a plant used in traditional Chinese medicine for inflammation. Researchers tested it against kidney damage caused by high blood pressure and report it cut inflammation, oxidation and scarring by changing how kidney cells clear out damaged parts and by blocking one form of cell death. All of this was done in animals and cells, not in people. There is no evidence yet that it helps a person with kidney disease.

Who did this work

Cui X · Yang D · Zhang Z · Wang C · Li H · Sun J · Zhang T · Wang M

Source

Article · PubMed, Climate, heat and the kidney · 2026 Aug 28
https://pubmed.ncbi.nlm.nih.gov/42665168/