← brief for 2026-08-21 · People & money

MHY@MO@PPP inhibits ferroptosis positive feedback and delays the acute kidney injury-to-chronic kidney disease transition by remodeling the Fe2+-mTORC1-GPX4 axis

Paper D Not peer reviewed Preclinical

Key takeaways

A compound called MHY@MO@PPP stopped a harmful cycle of iron buildup and cell death in rats with acute kidney injury, and slowed the shift to long-term kidney disease. This was tested only in animals — not people — so it is not ready for clinical use.

Who did this work

Chenhao Li (Jilin University) · Chao Zhang (Jilin University) · Chuanqi Zhang (Jilin University) · Shiyu Duan (Jilin University) · Jiali Zhang (Jilin University) · Hongyue Wang (Jilin University)

Source

Paper · OpenAlex, Kidney disease concept sweep (verified C2778653478) · 2026-08-20
https://doi.org/10.1186/s12951-026-04918-w