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Local ancestry-aware genome-wide meta-analysis uncovers novel genetic loci for sickle cell disease nephropathy

Paper C Peer reviewed Observational

Key takeaways

Researchers combined genetic data from many people to hunt for genes tied to kidney disease in sickle cell disease. They found new genetic spots linked to it, using a method that accounts for people's mixed ancestry. This shows genes that travel with the disease; it is not proof of a cause or a treatment.

Who did this work

Melanie E. Garrett (Duke Medical Center) · Mehdi Nouraie (University of Pittsburgh) · Roberto F. Machado (University of Maryland, Baltimore) · Victor R Gordeuk (University of Illinois Chicago) · Mark T. Gladwin (University of Maryland, Baltimore) · Marilyn J. Telen (Duke Medical Center) · Allison E Ashley-Koch (Duke University) · NHLBI Trans-Omics for Precision Medicine (TOPMed) (National Heart Lung and Blood Institute)

Source

Paper · OpenAlex, Kidney disease concept sweep (verified C2778653478) · 2026-08-19
https://doi.org/10.1182/bloodadvances.2026020894