← brief for 2026-08-21 · People & money

Injured proximal tubule-driven paracrine signaling promotes lipid-associated macrophage expansion and chondroitin sulfate biosynthesis via PPARG/TCF12 in diabetic kidney disease

Paper D Not peer reviewed Preclinical

Key takeaways

In the test tube and in mice, injured kidney cells sent signals that changed immune cells to store more fat — a process involving two proteins called PPARG and TCF12. This has not been tested in people yet, so it is too early to know if it matters for human kidney disease.

Who did this work

Bingshu Wu (Naval Medical Research Command) · Zihan Dou (Fudan University) · Ming Cai (Fudan University) · Siying Fei (Naval Medical Research Command) · Suxuan Liu (Naval Medical Research Command) · Xiaobin Mei (Naval Medical Research Command)

Source

Paper · OpenAlex, Kidney disease concept sweep (verified C2778653478) · 2026-08-20
https://doi.org/10.3389/fimmu.2026.1882611