← brief for 2026-08-21 · Slowing decline

Indoxyl Sulfate Promotes Uremic Arterial and Venous Thrombosis by Stabilizing IDO1 via the E3 Ligase SHFM3.

Article D Peer reviewed Preclinical

Key takeaways

In test tubes and animals, a toxin called indoxyl sulfate makes blood clots more likely by stabilizing a protein named IDO1, which may explain why people with kidney disease have higher clot risk. This work was done in cells and animals, not people yet.

Who did this work

Almiron R · Malloum AB · Lotfollahzadeh S · Sethuraman K · Sharma A · Selinger I · Natrakul A · Patel A · Wong DJW · Chowdhury F · Jose A · Carmen Piqueras MD

Source

Article · PubMed, CKD severity and reversal · 2026 Aug 21
https://pubmed.ncbi.nlm.nih.gov/42627700/