← brief for 2026-08-21 · Slowing decline

Advanced glycation end products and RAGE signaling in diabetic cardiomyopathy: distinct mechanisms, human evidence, and translational barriers

Paper C Peer reviewed Observational

Key takeaways

High blood sugar in diabetes can lead to harmful compounds that damage the heart and kidneys through a signaling pathway called RAGE — human studies support this, but more research is needed to turn it into a treatment. This study links biology to disease but does not prove cause and effect.

Who did this work

Zhiqiang Wang (Yangtze University) · Qingbo Shi (Zhengzhou Central Hospital) · Xiaoya Li (Yangtze University) · Zhiwen Zhang (Zhengzhou Central Hospital) · Muwei Li (Zhengzhou Central Hospital)

Source

Paper · OpenAlex, CKD works · 2026-08-20
https://doi.org/10.3389/fcvm.2026.1846184