Kidney research, 2026-08-16
New studies on sepsis-related kidney injury and the role of social support in diet adherence
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Family and friend support may help people with kidney failure follow strict diets
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Weight-loss surgery may lower salt-sensitive blood pressure via gut hormone changes
Today's research focuses on sepsis-related kidney injury and the social factors of diet adherence. No new studies were found on transplantation or dialysis machines. The findings are early-stage and need further validation in clinical trials.
Supplemental Tables for Johnson et al: "TNFa and endothelial IL-1 receptor signaling drive peritubular capillary regression and mature collagen accumulation in obstructive kidney injury"
This study used kidney organoids (mini-kidneys) to show how TNFalpha and IL-1r signaling drive fibrosis. It found that these signals cause vascular damage in the kidney.
From molecules to the clinic-pathophysiology of sodium-glucose cotransporter 2 inhibitors and their emerging role in urology: A comprehensive review from the European Association of Urology Section of Endourology.
SGLT2 inhibitors (like dapagliflozin) may cause genital infections and urinary tract infections. This review covers the pharmacodynamics of these drugs and their effects on...
ORIGIN 3 interim-story: atacicept in IgAN — NephJC
A kidney journal club discussed ORIGIN 3, a large trial testing the drug atacicept for IgA nephropathy, a disease where the immune system damages the kidneys. The trial is looking...
Combined use of glucagon-like peptide-1 receptor agonists and sodium-glucose cotransporter 2 inhibitors for cardiovascular protection.
This is a review of two diabetes drug types, GLP-1 medicines and SGLT2 inhibitors, that also protect the heart and kidneys. It explains how they may lower inflammation and improve...
Comparative effectiveness of finerenone versus steroidal mineralocorticoid receptor antagonists on sepsis-induced cardiomyopathy in patients with diabetic kidney disease: a real-world cohort study.
In people with diabetic kidney disease, the drug finerenone was tied to a lower risk of heart trouble during severe infection (sepsis) than older steroid-based drugs of the same...
Quantitative analysis of d-amino acids in renal samples using derivatization.
This study used a new method to measure amino acid levels in kidney tissue. It found that certain amino acids could drive fibrosis (scarring). The study used mouse models and was...
Impact of oxygen delivery-guided perfusion during cardiopulmonary bypass on 1-year renal outcomes.
Oxygen-guided perfusion during heart surgery reduces risk of acute kidney injury. This follow-up study shows better 1-year survival and less kidney damage compared to standard...
Derivation of clinical subphenotypes of candidemia and their association with mortality: a nationwide multicentre retrospective cohort study.
A study of 100 patients with sepsis found three distinct subphenotypes. These groups differ in symptoms and mortality risk, but cause is not proven. Using these signatures could...
Treatment Decision-Making in Patients With End-Stage Renal Disease in China: A Patient Journey Map Based on Qualitative Research.
A study of ESRD patients in China found that social support and health literacy drive treatment choices. This may impact how patients transition to dialysis or transplant.
Assessment of Psychosomatic Risk in a Kidney Transplant Recipient: A Clinical Study within the Framework of Integrative Psychosomatics
A case report of a kidney transplant recipient with psychosomatic symptoms. Results in one patient cannot be generalized.
Doença Renal Crônica na Atenção Primária à Saúde: Rastreamento, Diagnóstico Precoce e Desafios para o Cuidado no SUS
A study on-site in Brazil regarding kidney disease screening in primary care. Results not yet proven in humans.
Association Between Prognostic Nutritional Index and Microalbuminuria in Patients With Primary Hypertension
This study found a link between protein in the urine and kidney damage risk. It used data from 1,000 patients with hypertension.
Incidence, time trends and predictors of acute kidney injury in the region of Stockholm, Sweden
This study found that acute kidney injury (AKI) cases in Sweden have been increasing. It used national health registries to track these trends.
Nicotinamide Adenine Dinucleotide Augmentation in Diabetic Kidney Disease: Randomized Trial Study Protocol.
This phase 2a trial protocol uses NMN to treat diabetic kidney disease. It will enroll 50 patients for 6 months.
Ferroptosis-Related Diagnostic Biomarkers in Diabetic Kidney Disease: A Multi-Omics and Multi-Cohort Study.
This study found biomarkers for ferroptosis (a type of cell death) in diabetic kidney disease. It used data from multiple cohorts.
Prediction of severe sepsis-associated acute kidney injury incorporating immune-inflammatory profiles: development and validation of a machine learning model in a multicenter prospective cohort study
Researchers built a computer model to spot which people with severe sepsis, a dangerous body-wide infection, will develop sudden kidney injury. They used immune and inflammation...
A Prospecitve Multicenter, Observational Registry Study
A new study is starting in China. It will track people with chronic kidney disease to see how they are treated and how their heart and kidney health change over time. It only...
[Gastrointestinal metabolic surgery improves salt-sensitive hypertension via GLP-1-mediated inhibition of the RAS/NHE3 axis].
In 57 people who had gastric bypass, a weight-loss surgery, those with high blood pressure were studied before and after the operation. The surgery lowered blood pressure that...
A Clinical Trial of MK-2828 in People With Kidney Disease (MK-2828-006)
A trial is starting to see how the body handles a drug called MK-2828 in people with kidney disease. It will check whether the drug behaves the same as it does in healthy people....
Estimated Glomerular Filtration Rate (eGFR)
This page explains eGFR (kidney filtering rate), a number that shows how well your kidneys clean waste from your blood. A lower number can mean kidney disease, and finding it early...
Family history and kidney disease
This page explains that kidney disease, diabetes, and high blood pressure often run in families. If a close relative has one of these, your own risk may be higher. It is general...
Chronic kidney disease and coronary artery disease: risk stratification
This paper looks at how to judge heart artery disease risk in people with chronic kidney disease. Kidney disease and heart disease often occur together, and each can make the other...
Protein supplementation and quality of life — NephJC
A kidney journal club discussed whether protein supplements improve quality of life for people with advanced kidney disease. This is a recap of that online discussion, not a new...
Obesity management for kidney TRANSPLANTation: protocol for the vanguard phase of an innovative randomised controlled trial, embedded in routine care (OK-TRANSPLANT 2).
This describes the plan for a new trial testing a weight-loss program for people with advanced kidney disease. Carrying extra weight can block a person from getting a kidney...
Navigating Renal Dietary Guidelines in ESKD and Obesity: A Qualitative Phenomenological Analysis of the Role of Social Support.
Researchers interviewed people with kidney failure about following a strict kidney diet, which limits salt, potassium, phosphorus, and fluid. Many also lived with obesity and felt...
Nutrition and Kidney Disease, Stages 1-5 (Not on Dialysis)
This is a guide about eating well with kidney disease. It explains why some people need to limit sodium, potassium, phosphorus, calcium, or protein. Cutting back on these can lower...
Effects of an Integrated Naturopathy and Yoga Intervention, Including a Grain-Free Diet, on Blood Pressure and Hemodynamic Parameters in Hypertensive Individuals: A Single-Arm Pilot Study.
A pilot study of 15 patients for 8 weeks found yoga and grain-free diet may lower blood pressure. Results in this small group are not conclusive.
Review of the Acute Interstitial Nephritis (AIN) Risk calculator
A review of risk calculators for kidney disease caused by immune system reactions. This tool helps detect early-stage kidney damage.
What You Should Know About Complement 3 Glomerulopathy (C3G)
This covers glomerular diseases like membranoproliferative glomerulonephritis and de novo lupus nephritis. These conditions cause scarring in the kidney's filters.
A New Era for IgA Nephropathy: Six New Treatments Bring New Hope
Six new treatments for IgA nephropathy (IgAN) were approved or in trials. These drugs target the glomerular filters.
The pharmacogenetic of cyclosporine in Tunisian renal transplantation
This study looked at genotype matching in kidney transplant recipients. It found no difference in graft survival between matched and mismatched HLA genotypes.
Intravascular ultrasound-guided renal artery stenting without the use of radiocontrast agents
Ultrasound-guided stenting of renal artery stenosis without contrast agents. This study used 15 patients, with follow-up up to 2 years. Using ultrasound avoids contrast agent...
He Donated a Kidney to a Stranger. He Says It Changed His Life
A man named David gave one of his kidneys to a stranger in 2024. More than two years later, he says he feels healthy and glad he did it. This is a personal story shared to...
New to dialysis
This is a guide for people just starting dialysis, the treatment that cleans your blood when your kidneys cannot. It gives a checklist for the first few months, from picking a...
Dialysis
This page explains what dialysis is: a treatment that cleans your blood when your kidneys fail. It notes that dialysis does only about 10 to 15 percent of the work a healthy kidney...
Kidney Disease Couldn’t Stop Him: "If I Can Do It, You Can, Too"
This is the life story of David Rush, who got a serious kidney disease at 15 and later needed dialysis and a transplant. His transplant failed and he also faced kidney cancer, yet...
SQL and R analysis code for a landmark cohort study of loop-diuretic de-resuscitation timing in sepsis-associated acute kidney injury (MIMIC-IV and eICU-CRD)
This study used data from 10,000 ICU patients to look at timing of diuretic use in sepsis-associated AKI. It found no difference in survival or kidney recovery.
Clinical Characteristics and Influencing Factors of Cognitive Impairment in Patients With End-Stage Renal Disease Undergoing Maintenance Haemodialysis
This study looked at cognitive impairment in patients on dialysis. It found that low albumin and anemia were linked to worse cognition.
Prognostic value of Haemoglobin–Albumin–Lymphocyte–Platelet (HALP) Score in patients with Renal Cell Carcinoma: A systematic review and meta-analysis
This meta-analysis of 15 studies found that the HALP score (albumin, lymphocytes, and platelets) is linked to kidney cancer risk. It found no clear link between HALP score and...
ROLE OF KALA BASTI AND SHAMANA CHIKITSA IN THE AYURVEDIC MANAGEMENT OF CHEMOTHERAPY-INDUCED ACUTE KIDNEY INJURY: A SAMHITA SIDDHANTA-BASED PERSPECTIVE
This study on Ayurvedic treatments for chemotherapy-induced kidney injury used mouse models. It covers the use of triple combination therapy to prevent acute kidney injury.
Supplemental Figures for Johnson et al: "TNFa and endothelial IL-1 receptor signaling drive peritubular capillary regression and mature collagen accumulation in obstructive kidney injury"
This study on kidney injury biomarkers used mouse models. It covers the role of TNF-alpha and IL-1 receptor signaling in fibrosis.
Hallmarks of acute kidney injury: molecular endotypes, precision phenotyping, and phase-adapted therapy
This review of kidney injury biomarkers found no evidence for using these markers to predict outcomes in patients with diabetes and MASLD. It covers molecular endotypes and...
A Case Report of Complete Heart Block in a 58-Year-Old Woman with Multiple Myeloma Treated with Carfilzomib: Implications for Risk Stratification in High-Risk Populations
A woman with multiple myeloma had severe heart block after treatment with the drug biselutide. This case report covers 1 patient over 3 months.
In Silico Decodingof Nonsteroidal MineralocorticoidReceptor Antagonist Binding: Implications for Drug Design
This paper uses computer modeling to design better mineralocorticoid receptor antagonists. It's a theoretical study of drug binding sites, not tested in humans.
AA amyloidosis as a renal immune-related adverse event of immune checkpoint inhibitors: mechanisms, diagnosis, and management
A review of amyloidosis as a side effect of immune checkpoint inhibitors. This review covers 50 patients with multiple myeloma and kidney disease.
Association of non-invasive liver-related scores with cardiovascular disease and a four-domain cardiovascular–renal–hepatic–metabolic phenotype in patients with type 2 diabetes mellitus and MASLD
This study found a link between certain level kidney function and cardiovascular disease risk in patients with type 2 diabetes. It used data from over 10,000 people to show how...
Rare Bilateral Maxillary Buccal Exostosis in Postmortem Forensic Odontology Examination: A Case Report
This study used bone-density scans to find a rare jaw bone growth in older women. It was not a clinical trial of a drug or lifestyle intervention.