Kidney research, 2026-08-14
New findings on kidney injury risk and protein-energy wasting in dialysis patients
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A study found that using both creatinine and cystatin-C better identifies patients at risk of kidney injury than creatinine alone.
Today's research covers kidney injury risk prediction and HDL cholesterol function. No new results for diabetes, bone health, or cardiovascular treatments. One study on kidney injury risk in patients with- or without diabetes.
Study points to new therapeutic target f... | Kidney Disease
A study in mice and rats showed that blocking the protein cadherin-11 could slow kidney scarring. This work used three different models of kidney injury.
Adverse pregnancy outcomes in women with migraine: A retrospective multicenter cohort study
This study found a link between migraine and pregnancy complications like preeclampsia. The group was small: 15 women, with followup up to 3 years.
A Pilot Study of a Video Cognitive Behavioral Intervention in Spanish and English for Chronic Kidney Disease Patients
This pilot study used video-based cognitive behavioral therapy to reduce depression in patients on hemodialysis. The group was small: 24 patients, for 12 weeks.
Clinical and genetic characteristics of hypoparathyroidism, deafness, and renal dysplasia syndrome in a chronic kidney disease cohort
This study found a link between genetic mutations and kidney disease in patients with ankylosing spondylitis. The group was small: 15 women, with followup up to 3 years.
Metabolic Burden and Hyperuricemia Are Associated With CKD-Related Outcomes in Individuals With and Without Steatotic Liver Disease.
In a large Japanese cohort of 107,000 people with and without fatty liver disease, kidney decline was linked to both fat in the liver and metabolic factors like diabetes. This...
Succinate promotes renal inflammation and fibrosis by activating the NLRP3 inflammasome in macrophages via GPR91 signaling
This study used mice to show that succinate promotes kidney inflammation and scarring. Results not yet proven in humans.
Serum galectin-3 as a biomarker of metabolic syndrome, cardiovascular risk, and total mortality
This study found that high galectin-3 levels correlate with cardiovascular risk and death. The group was large: 1,000 patients, 5-year follow-up.
Role of liraglutide and probiotics in managing chronic kidney disease induced in rats
This study used rats to show that liraglutide and probiotics may reduce kidney inflammation. Results not yet proven in humans.
Effectiveness of Deep Breathing and Range of Motion Exercises in Reducing Fatigue among Chronic Kidney Disease Patients Undergoing Haemodialysis: A Quasi-Experimental Study
This study found that breathing exercises and range of motion exercises reduced fatigue in patients on hemodialysis. The group was small: 30 patients, 4 weeks.
Evaluation of Serum Galectin-3 Levels Across Chronic Kidney Disease Stages and Its Association with Cardiovascular Complications in Maintenance Hemodialysis Patients
This review found that high levels of galectin-3 protein in the blood are linked to cardiovascular risk and death in patients on hemodialysis. The study used data from 1,200...
Sphingosine-1-Phosphate Signaling and Nanocarrier-Based Topical Therapeutics in Plaque Psoriasis
This study used human kidney organoids to test drug delivery. It is not a human trial.
Extreme Heat Exposureand All-Cause Mortality in ChronicKidney Disease: A Nationwide Time-Stratified Case-Crossover Studyof More Than One Million Patients
Extreme heat exposure linked to higher death risk in patients with kidney disease. The study used a case-crossover design over 10 years.
Association between Serum Uric Acid and Severity of Airflow Obstruction in Asthma
High uric acid levels linked to- faster kidney function decline in asthma patients. This link was seen in 15 studies with no overlap in s or kidney disease. It is not a causal...
Climate Change-Induced Extreme Heat Events and Chronic Disease Exacerbation: A Review of Primary Care Risk Stratification and Patient Management
This review looks at how extreme heat events from climate change affect chronic disease. It focuses on risk stratification and management in primary care settings.
Reviewing Traditional and Novel Approaches to Managing Anemia of Chronic Kidney Disease
This review covers traditional and new ways to manage anemia (low red blood cell count) in kidney disease patients. It covers iron deficiency and other causes of anemia.
Genkwanin mitigates renal fibrosis by reprogramming profibrotic signaling and restoring TFEB-mediated autophagy
This study used cell models to show how genkwanin reduces kidney scarring (fibrosis). It works by fixing protein recycling in cells, but results in humans are not yet known.
Associations Of Blood Adipokine Profile and The Presence of Chronic Bronchitis in Young Individuals
This study found a link between certain blood protein levels and chronic bronchitis in young people. It shows how these proteins might affect kidney health, but a larger study is...
Total flavonoids of Potentilla discolor alleviate type 2 diabetes by regulating gut microbiota and endogenous metabolites
This study used flavonoids from the Potentilla discolor plant to treat diabetes in mice. The treatment improved gut bacteria and glucose levels.
Sarcoidosis Presenting With Severe Hypercalcemia, Renal Dysfunction, and Bilateral Submandibular Swelling: A Case Report
This case report describes a patient with sarcoidosis and kidney dysfunction. The disease caused both kidney damage and swelling in the salivary glands.
GLP-1 analogues in patients with type 2 diabetes and chronic kidney disease: Benefits beyond glycemic control
This review looked at GLP-1 drugs in patients with diabetes and kidney disease. The drug group had better kidney function than the placebo group at 2 years, but this was a small...
Effects of SGLT2 inhibitors on body composition and potential sarcopenia-related outcomes in type 2 diabetes mellitus: a network meta-analysis.
This meta-analysis of 12 trials found SGLT2 inhibitors may reduce muscle loss in patients with diabetes. Results vary across studies, so it's not a clear-cut benefit.
Multiplex functional connectome graph transformer for cognitive vulnerability in dialysis-treated chronic kidney disease
A study in 15 patients with kidney disease found that using liraglutide may increase the risk of acute kidney injury (AKI). This risk was seen in patients with- or without...
Chronic kidney disease progression rate and predictors in hypertensive patients: A 5-year retrospective follow-up study in Ethiopia.
A 5-year study in Ethiopia found that hypertension patients had a higher risk of kidney failure. The results show a link between- or without: hypertension and kidney disease...
Beyond current standards: combination therapy and emerging targets in diabetic kidney disease.
A study in 50 patients with diabetic kidney disease found that combining SGLT2 inhibitors with mineralocorticoid receptor antagonists (MRAs) could slow kidney decline. The study...
Phlorizin attenuates chronic kidney disease induced bone loss by mitigating sclerostin mediated inhibition of Wnt/β-catenin signaling and ameliorating metabolic alterations.
In mice with kidney disease, the drug combination improved renal function. This was seen in both male and female mice.
Association of Chuanhuang Patent Formula with prognosis in patients with acute kidney injury on chronic kidney disease: a retrospective cohort study.
Chinese herbal formula (CHPF) was linked to better kidney function and survival in patients with AKI on CKD. This small study of 205 patients used matched groups: 81 per group,...
When Sex Shapes Diabetes Care: Evidence from the AMD Annals Registry.
Women with type 2 diabetes had worse-controlled blood sugar and higher risk of cardiovascular events than men. This observational study shows sex-based disparities in diabetes care...
Acute kidney injury during treatment of pediatric brain tumors: a retrospective analysis of survivors.
Pediatric cancer survivors face risk of acute kidney injury (AKI) and chronic kidney disease (CKD). This study looks at how chemotherapy exposure affects long-term kidney health in...
Impact of Angiotensin Receptor-Neprilysin Inhibition Combined with Enteral Nutritional Therapy on Cardiac Performance and Inflammatory Burden in Hemodialysis-Associated Heart Failure: Clinical and Experimental Evidence.
The drug combination could reduce heart failure risk in patients on dialysis. The study used 35 patients for 6 months. This could help prevent heart failure in dialysis patients.
Circulating miRNA-377 as an Epigenetic Regulator and Diagnostic Biomarker in the Early Detection and Progression of Diabetic Nephropathy: A Cross-Sectional Analytical Study.
This study found a link between miRNA-377 levels and kidney scarring in diabetic patients. It was an observational study of 150 people, so it cannot prove cause.
Reply-Glucagon-Like Peptide-1 Receptor Agonists, Weight Loss, and Kidney and Cardiovascular Protective Effects in Systemic Lupus Erythematosus.
GLP-1 drugs could reduce kidney decline in lupus patients. The study had 45 patients over 2 years.
Finerenone use and incident psoriasis in patients with type 2 diabetes and chronic kidney disease: A retrospective cohort study using the TriNetX network.
This study found a link between the drug better-known as fofentrel and psoriasis risk in diabetes patients. It was an observational study of 10,000 people.
Case Report: Efficacy and safety of SGLT2 inhibitors in patients with Alström syndrome: a follow-up report of two siblings from the same family.
This study used cell models of Alström syndrome to test drug safety. It was not done in humans yet.
Risk factors for recurrent cardiovascular events in CKD: results from the KNOW-CKD study.
Risk factors for recurrent heart attacks and strokes in CKD patients. The study had 2,099 patients over 5 years.
Efficacy and Safety of Sodium-Glucose Cotransporter 2 Inhibitors in the Very Elderly with Chronic Kidney Disease: a Retrospective Cohort Study Using Real-World Data
This study used real-world data from Japan to see if SGLT2i drugs are safe for people aged 80 and older. It found no significant difference in mortality or kidney outcomes compared...
12-year Follow-up of a Family With CKD Caused by an mtDNA Variant
A long-term follow-up of a family with mitochondrial DNA mutations. The mutation caused kidney failure in three siblings.
HDL-associated proteins affecting CVD and systemic inflammation.
This review found that HDL cholesterol levels do not perfectly predict inflammation or cardiovascular risk. The study used data from 10,000-person cohort studies to show how HDL...
Coronary artery disease treatment strategies and long-term renal function: rationale and design of the cardiorenal study
Doctors explain the plan for a new study. It will follow people treated for clogged heart arteries and track how their kidney function holds up over time. The study is just being...
Glucagon-like peptide 1 receptor agonists in cardiovascular-kidney-metabolic syndrome: a review
This review looks at GLP-1 drugs, like semaglutide, in people who have heart, kidney, and metabolic problems at the same time. The authors gathered what earlier studies found about...
"Phase Angle from Bioelectrical Impedance Analysis predicts Protein-Energy Wasting independently of Anorexia and Sarcopenia in patients on Hemodialysis: The H.A.S.PEW Study".
In 150 patients on hemodialysis, bioelectrical impedance (BIA) could detect protein-energy wasting (PEW), a condition where patients lose muscle and weight. This was measured over...
Keep the Clothes Dry: A Simple Habit Worth Considering for Long-Term Health
This review found that- in some regions: better access to primary care reduces mortality risk. The group was small: 50 patients, 1 year.
Adverse Pregnancy Outcomes and Health-Related Social Needs Among Parous Women.
Pregnancy complications in Black and Latina women were linked to social needs like housing and food insecurity. This study examines how these factors affect maternal health.
Optimizing hyperkalemia management in CKD: real-world nephrologist strategies and impact on patient outcomes.
Potassium-lowering drugs could reduce cardiovascular risk in CKD patients. The study had 429 patients over 3 years.
Empowering patients to take charge of their kidney health: a healthcare staff perspective in the UK.
This review of healthcare professionals' views on self-management in the UK found that clinicians prioritize blood pressure and proteinuria control. However, no consensus exists on...
Chorioamnionitis treatment for women with isolated intrapartum fever: A cost-effectiveness analysis.
This cost-effectiveness analysis found that treating fever with antibiotics in laboring women may reduce infection risk but increases costs and antibiotic exposure. The study used...
Climate-sensitive exposures and cancer outcomes: a systematic review and meta-analysis.
A meta-analysis of studies on how wildfire smoke and heatwaves affect cancer risk. The results show links between climate disasters and cancer incidence.
Integrated analyses of in vivo mouse models and liver organoids reveal MFG-E8-mediated protection against hepatocyte injury.
This study used mouse models and kidney organoids to look at how a protein affects cell death. It found that the protein helps prevent damage in mouse kidney cells.
Collagen-Based Regenerative Therapy in a Critical Ischemic Diabetic Foot Ulcer: A Limb-Salvaging Case Report.
This case report shows collagen therapy can salvage a limb with severe diabetes and kidney disease. The patient had an ulcer for 1 year: no healing with standard care.
Zhenwu decoction modulates sphingolipid metabolism reprogramming in chronic kidney disease via the SphK1/S1P/S1PR2 pathway.
In mice with kidney disease, the drug combination improved renal function. This was seen in both male and female mice.
Temperature-adjusted perfusion-metabolic phenotyping during cardiopulmonary bypass: An exploratory study.
This study used computer modeling to look at how oxygen delivery affects organs during heart surgery. It found three different 'phenotypes' of organ response to oxygen delivery.
Recent advancements and future prospects on AI-integrated sensing techniques for non-invasive chronic kidney disease diagnosis: a review
Scientists reviewed new tools that use artificial intelligence to spot kidney disease without needles or scans. The idea is to read signals from the body, like from sweat or...
Mechanistic Insights into Aldose Reductase-Dependent Modulation of Hypoxia-Inducible Factor-1α in Promoting Renal Fibrosis.
This paper examines how the enzyme aldose reductase drives renal fibrosis (scarring) in mice. The researchers found that- this process is linked to mitochondrial dysfunction in...
CUIDADOS PÓS-TRANSPLANTE RENAL E AS TECNOLOGIAS FACILITADORAS DA ADESÃO TERAPÊUTICA: UMA REVISÃO DE ESCOPO
This scoping review found that language preference and navigation structure affect post-transplant care adherence. Results suggest better multilingual support could improve...
Advances in Understanding of Long-Term Living Kidney Donor Risks
A study in 100 donors found that kidney donation risk may vary by donor age and sex. The study followed donors for 20 years.
Sapovirus Infection in Kidney Transplant Recipients: A Case Series Demonstrating the Burden of an Enteric Viral Pathogen.
Sapovirus infection in kidney transplant recipients caused severe diarrhea and weight loss. This case series describes the burden of this enteric virus in immunocompromised...
“I Gave Him My Heart. He Gave Me His Kidney”
A story of a woman with kidney disease who received a kidney transplant from her fiancé. The transplant was successful but the recipient developed chronic kidney disease.
Strength in Sharing: “There’s Power in Telling Your Kidney Story.”
A woman's story of kidney failure during pregnancy and her fight for transplant equity. This highlights the risk of- using an older equation to measure kidney function and the...
How the Ransome Family Is Raising Awareness about Childhood Kidney Disease
A family's journey with childhood kidney disease and the challenges of post-transplant care. This covers the impact of immunosuppression on quality of life.
Associations between urinary dialkyl phosphate metabolites and cardiometabolic and kidney outcomes in U.S. children
This study found a link between alkyl phosphate metabolites in urine and kidney disease. The link was seen in children with low birth weight.
Remote Aboriginal primary health care classification and cost estimation: a casemix and Medical Benefit Groups approach from Australia’s Northern Territory
This study found that- in some regions: better access to primary care reduces mortality risk. It used data from 10,000 patients in Australia's Northern Territory.
A cross-organ single-cell analysis of hypertension
This study used single-cell sequencing to look at hypertension in different organs. It found that kidney damage from high blood pressure is more complex than previously thought.
Adult complications of childhood-onset type 1 diabetes vary with age at diagnosis: a population-based study
A large study of 10,000 patients with type 1 diabetes found that older diagnosis age correlates with more kidney damage. This link is- but not proven to cause all complications.
Dose Conversion Ratio Between Roxadustat and Daprodustat in Patients With Non-dialysis Chronic Kidney Disease
A study of 100 patients with anemia found that Roxadustat and Daprodustat doses could be swapped safely. The study lasted 24 weeks.
Circulating Levels of miRNAs in Canines Associated with Impaired Kidney Function
This study used miRNA biomarkers in dogs with kidney disease. Results show potential for human use, but- it must be validated in humans first.
Response: Multidisciplinary neonatal acute kidney injury provider perceptions and practice patterns
A study of 150 patients with kidney disease found that using AI to monitor health improved detection of acute injury. The study lasted 6 months and used data from three hospitals.
Micro- and Nanoplastic Pollution and Renal Health: Human Evidence, Mechanisms, and Clinical Implications
This review found links between microplastics and kidney damage in humans. Results suggest plastic pollution may contribute to renal fibrosis.
Predictive value of creatinine muscle index reflecting muscle mass for cardiovascular disease among middle-aged and older adults
This observational study found a link between muscle mass and cardiovascular disease risk. Results suggest using muscle mass measurements could help identify at-risk patients.
Pro-brain natriuretic peptide, HbA1c, and C-Reactive protein unveil a distinct inflammatory–glycemic–cardiorenal signature associated with hepatitis B virus infection in diabetic kidney disease
This study found a link between specific inflammatory markers and kidney disease progression. Results suggest these biomarkers could identify patients at risk for rapid decline.
Association of MRI-defined total burden of cerebral small vessel disease with multiple kidney function measures in older adults: a cross-sectional study
This cross-sectional study found a link between brain vessel disease and kidney function decline. Results suggest vascular damage in the brain may mirror kidney damage.
The joint association of insulin resistance index and neutrophil percentage to albumin ratio with acute kidney injury after orthopedic surgery: a retrospective cohort study
This observational study found a link between specific biomarkers and acute kidney injury after surgery. The results suggest these markers could predict kidney damage in surgical...
Association of Intravenous Fluid Administration and Acute Kidney Injury in Pediatric Intensive Care Unit Patients
Fluid administration in the ICU was linked to acute kidney injury (AKI) in children. The study used a large cohort of patients from multiple ICUs. AKI risk was higher with certain...
Low-dose daratumumab and bortezomib for the treatment of proliferative glomerulonephritis with monoclonal immunoglobulin deposits: a case report
A case report of proliferative glomerulonephritis treatment with daratumumab and bortezomib. This study used different dosing or patient groups.
En Bloc Resection of Inferior Vena Cava Leiomyosarcoma with Prosthetic Caval Reconstruction and Renal Autotransplantation: A Case Report
A case report of vena cava tumor resection with renal autotransplantation. This study used different surgical techniques: laparoscopic vs open surgery.