← brief for 2026-08-10 · Slowing decline

Glomerular-Targeted Delivery of Low-Dose Prednisolone Attenuates Established Lupus Nephritis in MRL/lpr Mice.

Key takeaways

Researchers used a delivery system to send a low dose of the steroid prednisolone straight to the kidney's filters in mice with a lupus-like kidney disease. It calmed the kidney damage. This was done in mice, not people, so it is an early result.

Who did this work

Kristof Williams (University of South Florida) · Georgina Agyekum (University of South Florida) · Akshata Patne (University of South Florida) · Eleni Markoutsa (University of South Florida) · David Raj Chellappan (University of South Florida) · Nathan Hall (University of South Florida) · Zhi Tian (University of South Florida) · Nohely Hernandez Soto (University of South Florida) · Sebastian Cuadrao (University of South Florida) · Isabella Lozonschi (University of South Florida) · Liying Fu (Mayo Clinic in Arizona) · Lilliana Haight (University of South Florida)

Source

Paper · OpenAlex, CKD concept sweep (DB seed + weekly delta) · 2026-08-06
https://doi.org/10.64898/2026.08.01.742194